Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics.
Identifieur interne : 000158 ( Main/Exploration ); précédent : 000157; suivant : 000159Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics.
Auteurs : You Jeong Park [États-Unis] ; Jeffrey Farooq [États-Unis] ; Justin Cho [États-Unis] ; Nadia Sadanandan [États-Unis] ; Blaise Cozene [États-Unis] ; Bella Gonzales-Portillo [États-Unis] ; Madeline Saft [États-Unis] ; Maximillian C. Borlongan [États-Unis] ; Mia C. Borlongan [États-Unis] ; R Douglas Shytle [États-Unis] ; Alison E. Willing [États-Unis] ; Svitlana Garbuzova-Davis [États-Unis] ; Paul R. Sanberg [États-Unis] ; Cesar V. Borlongan [États-Unis]Source :
- Stem cell reviews and reports [ 2629-3277 ] ; 2020.
Abstract
The human population is in the midst of battling a rapidly-spreading virus- Severe Acute Respiratory Syndrome Coronavirus 2, responsible for Coronavirus disease 2019 or COVID-19. Despite the resurgences in positive cases after reopening businesses in May, the country is seeing a shift in mindset surrounding the pandemic as people have been eagerly trickling out from federally-mandated quarantine into restaurants, bars, and gyms across America. History can teach us about the past, and today's pandemic is no exception. Without a vaccine available, three lessons from the 1918 Spanish flu pandemic may arm us in our fight against COVID-19. First, those who survived the first wave developed immunity to the second wave, highlighting the potential of passive immunity-based treatments like convalescent plasma and cell-based therapy. Second, the long-term consequences of COVID-19 are unknown. Slow-progressive cases of the Spanish flu have been linked to bacterial pneumonia and neurological disorders later in life, emphasizing the need to reduce COVID-19 transmission. Third, the Spanish flu killed approximately 17 to 50 million people, and the lack of human response, overcrowding, and poor hygiene were key in promoting the spread and high mortality. Human behavior is the most important strategy for preventing the virus spread and we must adhere to proper precautions. This review will cover our current understanding of the pathology and treatment for COVID-19 and highlight similarities between past pandemics. By revisiting history, we hope to emphasize the importance of human behavior and innovative therapies as we wait for the development of a vaccine. Graphical Abstract.
DOI: 10.1007/s12015-020-10026-5
PubMed: 32789802
PubMed Central: PMC7423503
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics.</title><author><name sortKey="Park, You Jeong" sort="Park, You Jeong" uniqKey="Park Y" first="You Jeong" last="Park">You Jeong Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Farooq, Jeffrey" sort="Farooq, Jeffrey" uniqKey="Farooq J" first="Jeffrey" last="Farooq">Jeffrey Farooq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Justin" sort="Cho, Justin" uniqKey="Cho J" first="Justin" last="Cho">Justin Cho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Sadanandan, Nadia" sort="Sadanandan, Nadia" uniqKey="Sadanandan N" first="Nadia" last="Sadanandan">Nadia Sadanandan</name><affiliation wicri:level="2"><nlm:affiliation>Georgetown University, 3700 O St NW, 20057, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Georgetown University, 3700 O St NW, 20057, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Cozene, Blaise" sort="Cozene, Blaise" uniqKey="Cozene B" first="Blaise" last="Cozene">Blaise Cozene</name><affiliation wicri:level="2"><nlm:affiliation>Tulane University, 6823 St. Charles Ave, 70118, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tulane University, 6823 St. Charles Ave, 70118, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Gonzales Portillo, Bella" sort="Gonzales Portillo, Bella" uniqKey="Gonzales Portillo B" first="Bella" last="Gonzales-Portillo">Bella Gonzales-Portillo</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, 633 Clark St, 60208, Evanston, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University, 633 Clark St, 60208, Evanston, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Saft, Madeline" sort="Saft, Madeline" uniqKey="Saft M" first="Madeline" last="Saft">Madeline Saft</name><affiliation wicri:level="2"><nlm:affiliation>University of Michigan, 500 S State St, 48109, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan, 500 S State St, 48109, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Borlongan, Maximillian C" sort="Borlongan, Maximillian C" uniqKey="Borlongan M" first="Maximillian C" last="Borlongan">Maximillian C. Borlongan</name><affiliation wicri:level="2"><nlm:affiliation>Tampa Preparatory School, 727 West Cass St, 33606, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tampa Preparatory School, 727 West Cass St, 33606, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Borlongan, Mia C" sort="Borlongan, Mia C" uniqKey="Borlongan M" first="Mia C" last="Borlongan">Mia C. Borlongan</name><affiliation wicri:level="2"><nlm:affiliation>University of California Berkeley, 94720, Berkeley, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California Berkeley, 94720, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shytle, R Douglas" sort="Shytle, R Douglas" uniqKey="Shytle R" first="R Douglas" last="Shytle">R Douglas Shytle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Willing, Alison E" sort="Willing, Alison E" uniqKey="Willing A" first="Alison E" last="Willing">Alison E. Willing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Garbuzova Davis, Svitlana" sort="Garbuzova Davis, Svitlana" uniqKey="Garbuzova Davis S" first="Svitlana" last="Garbuzova-Davis">Svitlana Garbuzova-Davis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Sanberg, Paul R" sort="Sanberg, Paul R" uniqKey="Sanberg P" first="Paul R" last="Sanberg">Paul R. 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sortKey="Farooq, Jeffrey" sort="Farooq, Jeffrey" uniqKey="Farooq J" first="Jeffrey" last="Farooq">Jeffrey Farooq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Justin" sort="Cho, Justin" uniqKey="Cho J" first="Justin" last="Cho">Justin Cho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Sadanandan, Nadia" sort="Sadanandan, Nadia" uniqKey="Sadanandan N" first="Nadia" last="Sadanandan">Nadia Sadanandan</name><affiliation wicri:level="2"><nlm:affiliation>Georgetown University, 3700 O St NW, 20057, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Georgetown University, 3700 O St NW, 20057, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Cozene, Blaise" sort="Cozene, Blaise" uniqKey="Cozene B" first="Blaise" last="Cozene">Blaise Cozene</name><affiliation wicri:level="2"><nlm:affiliation>Tulane University, 6823 St. Charles Ave, 70118, New Orleans, LA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tulane University, 6823 St. Charles Ave, 70118, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Gonzales Portillo, Bella" sort="Gonzales Portillo, Bella" uniqKey="Gonzales Portillo B" first="Bella" last="Gonzales-Portillo">Bella Gonzales-Portillo</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, 633 Clark St, 60208, Evanston, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Northwestern University, 633 Clark St, 60208, Evanston, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Saft, Madeline" sort="Saft, Madeline" uniqKey="Saft M" first="Madeline" last="Saft">Madeline Saft</name><affiliation wicri:level="2"><nlm:affiliation>University of Michigan, 500 S State St, 48109, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan, 500 S State St, 48109, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Borlongan, Maximillian C" sort="Borlongan, Maximillian C" uniqKey="Borlongan M" first="Maximillian C" last="Borlongan">Maximillian C. Borlongan</name><affiliation wicri:level="2"><nlm:affiliation>Tampa Preparatory School, 727 West Cass St, 33606, Tampa, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Tampa Preparatory School, 727 West Cass St, 33606, Tampa, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Borlongan, Mia C" sort="Borlongan, Mia C" uniqKey="Borlongan M" first="Mia C" last="Borlongan">Mia C. Borlongan</name><affiliation wicri:level="2"><nlm:affiliation>University of California Berkeley, 94720, Berkeley, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California Berkeley, 94720, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shytle, R Douglas" sort="Shytle, R Douglas" uniqKey="Shytle R" first="R Douglas" last="Shytle">R Douglas Shytle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Willing, Alison E" sort="Willing, Alison E" uniqKey="Willing A" first="Alison E" last="Willing">Alison E. Willing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Garbuzova Davis, Svitlana" sort="Garbuzova Davis, Svitlana" uniqKey="Garbuzova Davis S" first="Svitlana" last="Garbuzova-Davis">Svitlana Garbuzova-Davis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Sanberg, Paul R" sort="Sanberg, Paul R" uniqKey="Sanberg P" first="Paul R" last="Sanberg">Paul R. Sanberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author><author><name sortKey="Borlongan, Cesar V" sort="Borlongan, Cesar V" uniqKey="Borlongan C" first="Cesar V" last="Borlongan">Cesar V. Borlongan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA. cborlong@usf.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612</wicri:regionArea><wicri:noRegion>33612</wicri:noRegion></affiliation></author></analytic><series><title level="j">Stem cell reviews and reports</title><idno type="eISSN">2629-3277</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The human population is in the midst of battling a rapidly-spreading virus- Severe Acute Respiratory Syndrome Coronavirus 2, responsible for Coronavirus disease 2019 or COVID-19. Despite the resurgences in positive cases after reopening businesses in May, the country is seeing a shift in mindset surrounding the pandemic as people have been eagerly trickling out from federally-mandated quarantine into restaurants, bars, and gyms across America. History can teach us about the past, and today's pandemic is no exception. Without a vaccine available, three lessons from the 1918 Spanish flu pandemic may arm us in our fight against COVID-19. First, those who survived the first wave developed immunity to the second wave, highlighting the potential of passive immunity-based treatments like convalescent plasma and cell-based therapy. Second, the long-term consequences of COVID-19 are unknown. Slow-progressive cases of the Spanish flu have been linked to bacterial pneumonia and neurological disorders later in life, emphasizing the need to reduce COVID-19 transmission. Third, the Spanish flu killed approximately 17 to 50 million people, and the lack of human response, overcrowding, and poor hygiene were key in promoting the spread and high mortality. Human behavior is the most important strategy for preventing the virus spread and we must adhere to proper precautions. This review will cover our current understanding of the pathology and treatment for COVID-19 and highlight similarities between past pandemics. By revisiting history, we hope to emphasize the importance of human behavior and innovative therapies as we wait for the development of a vaccine. Graphical Abstract.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32789802</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2629-3277</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>13</Day></PubDate></JournalIssue><Title>Stem cell reviews and reports</Title><ISOAbbreviation>Stem Cell Rev Rep</ISOAbbreviation></Journal><ArticleTitle>Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12015-020-10026-5</ELocationID><Abstract><AbstractText>The human population is in the midst of battling a rapidly-spreading virus- Severe Acute Respiratory Syndrome Coronavirus 2, responsible for Coronavirus disease 2019 or COVID-19. Despite the resurgences in positive cases after reopening businesses in May, the country is seeing a shift in mindset surrounding the pandemic as people have been eagerly trickling out from federally-mandated quarantine into restaurants, bars, and gyms across America. History can teach us about the past, and today's pandemic is no exception. Without a vaccine available, three lessons from the 1918 Spanish flu pandemic may arm us in our fight against COVID-19. First, those who survived the first wave developed immunity to the second wave, highlighting the potential of passive immunity-based treatments like convalescent plasma and cell-based therapy. Second, the long-term consequences of COVID-19 are unknown. Slow-progressive cases of the Spanish flu have been linked to bacterial pneumonia and neurological disorders later in life, emphasizing the need to reduce COVID-19 transmission. Third, the Spanish flu killed approximately 17 to 50 million people, and the lack of human response, overcrowding, and poor hygiene were key in promoting the spread and high mortality. Human behavior is the most important strategy for preventing the virus spread and we must adhere to proper precautions. This review will cover our current understanding of the pathology and treatment for COVID-19 and highlight similarities between past pandemics. By revisiting history, we hope to emphasize the importance of human behavior and innovative therapies as we wait for the development of a vaccine. Graphical Abstract.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>You Jeong</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farooq</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Justin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadanandan</LastName><ForeName>Nadia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Georgetown University, 3700 O St NW, 20057, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cozene</LastName><ForeName>Blaise</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Tulane University, 6823 St. Charles Ave, 70118, New Orleans, LA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzales-Portillo</LastName><ForeName>Bella</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Northwestern University, 633 Clark St, 60208, Evanston, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saft</LastName><ForeName>Madeline</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Michigan, 500 S State St, 48109, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borlongan</LastName><ForeName>Maximillian C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Tampa Preparatory School, 727 West Cass St, 33606, Tampa, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borlongan</LastName><ForeName>Mia C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>University of California Berkeley, 94720, Berkeley, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shytle</LastName><ForeName>R Douglas</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willing</LastName><ForeName>Alison E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery and Brain Repair, University of South Florida Morsani 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Borlongan</name><name sortKey="Borlongan, Maximillian C" sort="Borlongan, Maximillian C" uniqKey="Borlongan M" first="Maximillian C" last="Borlongan">Maximillian C. Borlongan</name><name sortKey="Borlongan, Mia C" sort="Borlongan, Mia C" uniqKey="Borlongan M" first="Mia C" last="Borlongan">Mia C. Borlongan</name><name sortKey="Cho, Justin" sort="Cho, Justin" uniqKey="Cho J" first="Justin" last="Cho">Justin Cho</name><name sortKey="Cozene, Blaise" sort="Cozene, Blaise" uniqKey="Cozene B" first="Blaise" last="Cozene">Blaise Cozene</name><name sortKey="Farooq, Jeffrey" sort="Farooq, Jeffrey" uniqKey="Farooq J" first="Jeffrey" last="Farooq">Jeffrey Farooq</name><name sortKey="Garbuzova Davis, Svitlana" sort="Garbuzova Davis, Svitlana" uniqKey="Garbuzova Davis S" first="Svitlana" last="Garbuzova-Davis">Svitlana Garbuzova-Davis</name><name sortKey="Gonzales Portillo, Bella" sort="Gonzales Portillo, Bella" uniqKey="Gonzales Portillo B" first="Bella" last="Gonzales-Portillo">Bella Gonzales-Portillo</name><name sortKey="Sadanandan, Nadia" sort="Sadanandan, Nadia" uniqKey="Sadanandan N" first="Nadia" last="Sadanandan">Nadia Sadanandan</name><name sortKey="Saft, Madeline" sort="Saft, Madeline" uniqKey="Saft M" first="Madeline" last="Saft">Madeline Saft</name><name sortKey="Sanberg, Paul R" sort="Sanberg, Paul R" uniqKey="Sanberg P" first="Paul R" last="Sanberg">Paul R. Sanberg</name><name sortKey="Shytle, R Douglas" sort="Shytle, R Douglas" uniqKey="Shytle R" first="R Douglas" last="Shytle">R Douglas Shytle</name><name sortKey="Willing, Alison E" sort="Willing, Alison E" uniqKey="Willing A" first="Alison E" last="Willing">Alison E. Willing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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